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ProductsBack/Pseudolaric acid B [82508-31-4]
Chemical Structure
Chemical Structure
Chemical Structure

Pseudolaric acid B [82508-31-4]

Research Use Only
AG-CN2-0083
AdipoGen Life Sciences
CAS Number82508-31-4
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight432.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Pseudolaric acid B [82508-31-4]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    82508-31-4
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C23H28O8
  • Molecular Weight
    432.5
  • Scientific Description
    Antifungal and antifertility compound [1, 3]. Antitumor compound [2, 7-9, 13]. PPARalpha signaling agonist [4]. Angiogenesis inhibitor [5, 6, 11]. Apoptosis and autophagy inducer [7, 9, 15, 17]. Microtubule-destabilizing agent [8, 11]. Anti-inflammatory. Inhibits NF-kappaB and p38 signaling [12, 14]. Immunosuppressive [16]. - Chemical. CAS: 82508-31-4. Formula: C23H28O8. MW: 432.5. Isolated from Pseudolarix kaempferi. Antifungal and antifertility compound. Antitumor compound. PPARalpha signaling agonist. Angiogenesis inhibitor. Apoptosis and autophagy inducer. Microtubule-destabilizing agent. Anti-inflammatory. Inhibits NF-kappaB and p38 signaling. Immunosuppressive.
  • SMILES
    [H][C@@]12CC[C@]3(CC=C(CC[C@]13OC(C)=O)C(=O)OC)C(=O)O[C@]2(C)\C=C\C=C(/C)C(O)=O
  • Storage Instruction
    2°C to 8°C
  • UN Number
    UN 2811
  • UNSPSC
    12352200

References

  • Pseudolaric Acids from Pseudolarix kaempferi: B.N. Zhou, et al.; Planta Med. 47, 35 (1983)
  • The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives: D.J. Pan, et al.; Planta Med. 56, 383 (1990)
  • Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi: E. Li, et al.; J. Nat. Prod. 58, 57 (1995)
  • Pseudolaric acid analogs as a new class of peroxisome proliferator-activated receptor agonists: M.S. Jardat, et al.; Planta Med. 68, 667 (2002)
  • Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect: W.F. Tan, et al.; Eur. J. Pharmacol. 499, 219 (2004)
  • Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation: M.H. Li, et al.; Clin. Cancer Res. 10, 8266 (2004)
  • Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells: X.F. Gong, et al.; Arch. Pharm. Res. 28, 68 (2005)
  • Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo: V.K. Wong, et al.; Clin. Cancer Res. 11, 6002 (2005)
  • Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis: K.S. Li, et al.; World J. Gastroenterol. 11, 7555 (2005)
  • Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin: Y.G. Tong, et al.; Mol. Pharmacol. 69, 1226 (2006)