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PSMA antibody [YPSMA-1]

GTX19071
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetFOLH1
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Overview

  • Supplier
    GeneTex
  • Product Name
    PSMA antibody [YPSMA-1]
  • Delivery Days Customer
    9
  • Application Supplier Note
    For ELISA: Use at an assay dependent dilution. For IF: Use at an assay dependent dilution. For IHC-Fr: Use at an assay dependent dilution. For IHC-P: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher.
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    YPSMA-1
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2346
  • Target name
    FOLH1
  • Target description
    folate hydrolase 1
  • Target synonyms
    cell growth-inhibiting gene 27 protein; FGCP; FOLH; folylpoly-gamma-glutamate carboxypeptidase; GCP2; GCPII; glutamate carboxylase II; glutamate carboxypeptidase 2; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; mGCP; NAALAD1; NAALADase I; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; prostate specific membrane antigen variant F; PSM; PSMA; pteroylpoly-gamma-glutamate carboxypeptidase
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDQ04609
  • Protein Name
    Glutamate carboxypeptidase 2
  • Scientific Description
    This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA). Tykvart J et al., 2014 Dec, Prostate
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  • PSMA expression in Schwannoma: a potential clinical mimicker of metastatic prostate carcinoma. Wang W et al., 2009 Sep-Oct, Urol Oncol
    Read more
  • Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma. Mhawech-Fauceglia P et al., 2008 Mar, Cancer Epidemiol Biomarkers Prev
    Read more
  • Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray technique. Mhawech-Fauceglia P et al., 2007 Mar, Histopathology
    Read more

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