PTTG1 Polyclonal Antibody
RD85003A
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetPTTG1
Overview
- SupplierReddot Biotech
- Product NamePTTG1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID9232
- Target namePTTG1
- Target descriptionPTTG1 regulator of sister chromatid separation, securin
- Target synonymsEAP1; ESP1-associated protein 1; HPTTG; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein; PTTG; securin; tumor-transforming protein 1; TUTR1
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203