Pulrodemstat [1821307-10-1]

TargetMol Chemicals

Pulrodemstat [1821307-10-1]

16

1821307-10-1

Chemical

Research Use Only

Pulrodemstat

C24H23F2N5O2

451.478

Pulrodemstat (CC-90011) is a highly potent and selective inhibitor of lysine specific demethylase-1 (LSD1), exhibiting a reversible mode of action and oral bioavailability. With an impressive IC50 of 0.25 nM, Pulrodemstat effectively suppresses LSD1 enzymatic activity while demonstrating minimal inhibition of LSD2, MOA-A, and MAO-B enzymes. Additionally, Pulrodemstat possesses remarkable anticancer properties, promoting differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells.

3 years

COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1

-20°C

12352200