PX20606

MedChem Express

PX20606

5

C29H22Cl3NO4

554.85

PX20606 is an orally active agonist for farnesoid X receptor ( FXR ), with EC 50 220 nM (mFXR) and 50 nM (hFXR), measured by Gal4-FXR assay. PX20606 induces the expression of tumor suppressor gene NDRG2, inhibits the tumor growth and metastasis in mouse HCC model. PX20606 exhibits hepatoprotective efficacy [1] .

O=C(O)C(C=C1)=CC=C1C(C2)C2C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3Cl

12352200