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WB analysis of HeLa whole cell lysate using GTX81102 PXR antibody, Internal. Loading : 20 microg per lane Dilution : 1:1000
WB analysis of HeLa whole cell lysate using GTX81102 PXR antibody, Internal. Loading : 20 microg per lane Dilution : 1:1000
WB analysis of HeLa whole cell lysate using GTX81102 PXR antibody, Internal. Loading : 20 microg per lane Dilution : 1:1000

PXR antibody, Internal

GTX81102
GeneTex
TargetNR1I2
Product group Antibodies
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Overview

  • Supplier
    GeneTex
  • Product Name
    PXR antibody, Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000. ICC/IF: 1:10-1:50. IHC-P: 1:50-1:100. FACS: 1:10-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Formulation
    Liquid
  • Gene ID8856
  • Target name
    NR1I2
  • Target description
    nuclear receptor subfamily 1 group I member 2
  • Target synonyms
    BXR; nuclear receptor subfamily 1 group I member 2; ONR1; orphan nuclear receptor PAR1; orphan nuclear receptor PXR; PAR; PAR1; PAR2; PARq; pregnane X nuclear receptor variant 2; pregnane X receptor; PRR; PXR; SAR; steroid and xenobiotic receptor; SXR
  • Protein IDO75469
  • Protein Name
    Nuclear receptor subfamily 1 group I member 2
  • Scientific Description
    This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Deciphering structural bases of intestinal and hepatic selectivity in targeting pregnane X receptor with indole-based microbial mimics. Li H et al., 2021 Apr, Bioorg Chem
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  • Relationship between CYP3A29 and pregnane X receptor in landrace pigs: Pig CYP3A29 has a similar mechanism of regulation to human CYP3A4. He Y et al., 2018 Dec, Comp Biochem Physiol C Toxicol Pharmacol
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