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ProductsBack/Q-VD-OPh [1135695-98-5]
Chemical Structure
Chemical Structure
Chemical Structure

Q-VD-OPh [1135695-98-5]

Research Use Only
AG-CP3-0006
AdipoGen Life Sciences
CAS Number1135695-98-5
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight513.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Q-VD-OPh [1135695-98-5]
  • Delivery Days Customer
    10
  • CAS Number
    1135695-98-5
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C26H25F2N3O6
  • Molecular Weight
    513.5
  • Scientific Description
    Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies. - Chemical. CAS: 1135695-98-5 (anhydrous). Formula: C26H25F2N3O6. MW: 513.5. Synthetic. Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies.
  • SMILES
    CC(C)[C@H](NC(=O)C1=CC=C2C=CC=CC2=N1)C(=O)NC(CC(O)=O)C(=O)COC1=C(F)C=CC=C1F
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis 8, 345 (2003)
  • Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: a role for gender: S. Renolleau, et al.; J. Neurochem. 100, 1062 (2007)
  • The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities: T.T. Rohn; Apoptosis 15, 1403 (2010)
  • The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells: X. Chen-Deutsch, et al.; Leuk. Res. 36, 884 (2012)