Quetiapine Fumarate [111974-72-2]
Q8019
Estimated Purity≥98%
Product group Chemicals
Overview
- SupplierLKT Laboratories
- Product NameQuetiapine Fumarate [111974-72-2]
- Delivery Days Customer7
- CertificationResearch Use Only
- Estimated Purity≥98%
- Scientific Description5-HT1A and σ1/2 agonist, 5-HT2A/2C/6/7, D1-4, histamine H1/2, M1 mAChR, alfa1A/1B/2C-adrenergic antagonist.
- Storage InstructionAmbient
- UNSPSC12352200
References
- López-Muñoz F, Alamo C. Active Metabolites as Antidepressant Drugs: The Role of Norquetiapine in the Mechanism of Action of Quetiapine in the Treatment of Mood Disorders. Front Psychiatry. 2013 Sep 12;4:102. PMID: 24062697. Kotagale NR, Mendhi SM, Aglawe MM, et al. Evidences for the involvement of sigma receptors in antidepressant like effect of quetiapine in mice. Eur J Pharmacol. 2013 Feb 28;702(1-3):180-6. PMID: 23399765. Tempier A, He J, Zhu S, et al. Quetiapine modulates conditioned anxiety and alternation behavior in Alzheimer's transgenic mice. Curr Alzheimer Res. 2013 Feb;10(2):199-206. PMID: 22950914. Bi X, Zhang Y, Yan B, et al. Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice. J Neurochem. 2012 Oct;123(1):14-20. PMID: 22817262. Ichikawa J, Li Z, Dai J, et al. Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Res. 2002 Nov 29;956(2):349-57. PMID: 12445705. Richelson E, Souder T. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. PMID: 11132243.