R 80123
HY-100615A
Overview
- SupplierMedChem Express
- Product NameR 80123 [133718-30-6]
- Delivery Days Customer10
- CAS Number133718-30-6
- Estimated Purity98.0
- Molecular FormulaC26H29N5O3
- Molecular Weight459.54
- Scientific DescriptionR 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone). In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [3]
- SMILESO=C(N(C1CCCCC1)C)CO/N=C(C2=CC=CC=C2)\C3=CC4=C(N=C(NC(C5)=O)N5C4)C=C3
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200