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R 80123

HY-100615A
MedChem Express
CAS Number133718-30-6
Product group Chemicals
Estimated Purity98.0
Molecular Weight459.54
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Overview

  • Supplier
    MedChem Express
  • Product Name
    R 80123 [133718-30-6]
  • Delivery Days Customer
    10
  • CAS Number
    133718-30-6
  • Estimated Purity
    98.0
  • Molecular Formula
    C26H29N5O3
  • Molecular Weight
    459.54
  • Scientific Description
    R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone). In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [3]
  • SMILES
    O=C(N(C1CCCCC1)C)CO/N=C(C2=CC=CC=C2)\C3=CC4=C(N=C(NC(C5)=O)N5C4)C=C3
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200