Chemical Structure
(R)-CR8 [294646-77-8]
AG-MR-C0003
Overview
- SupplierAdipoGen Life Sciences
- Product Name(R)-CR8 [294646-77-8]
- Delivery Days Customer10
- CAS Number294646-77-8
- CertificationResearch Use Only
- Estimated Purity>98%
- Hazard InformationWarning
- Molecular FormulaC24H29N7O
- Molecular Weight431.5
- Scientific DescriptionChemical. CAS: 294646-77-8. Formula: C24H29N7O. MW: 431.5. Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) and glycogen synthase kinase (GSK-3alpha/beta) inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound. - Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Apoptosis inducer [1, 3, 4]. Inhibits the proliferation of various cancer cell lines [1]. Casein kinase 1 (CK1delta/epsilon) and glycogen synthase kinase (GSK-3alpha/beta) inhibitor [1, 2]. Potential anti-inflammatory compound. Potential antidiabetic compound.
- SMILESCC[C@H](CO)NC1=NC2=C(N=CN2C(C)C)C(NCC2=CC=C(C=C2)C2=NC=CC=C2)=N1
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200
References
- CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008)
- Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1: N. Oumata, et al.; J. Med. Chem. 51, 5229 (2008)
- CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells: K. Bettayeb, et al.; Genes Cancer 1, 369 (2010)
- CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury. S.V. Kabadi, et al.; Neurotherapeutics 9, 405 (2012)
- Inhibition of NF-kappaB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)