(R)-(-)-Gossypol

MedChem Express

(R)-(-)-Gossypol [90141-22-3]

10

90141-22-3

Research Use Only

98.82

C30H30O8

518.55

(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2 , Mcl-1 and Bcl-xL proteins with K i s of 260+/-30 nM, 170+/-10 nM, and 480+/-40 nM, respectively.

OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O

2°C to 8°C

12352200