(R)-(-)-Gossypol (AT-101) acetic acid

Selleck Chemicals

(R)-(-)-Gossypol acetic acid [866541-93-7]

9

866541-93-7

...

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 microM, 0.48 microM and 0.18 microM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

-80°C

12352200