(R)-Gyramide A (hydrochloride)

MedChem Express

(R)-Gyramide A (hydrochloride) [1793050-70-0]

10

1793050-70-0

Research Use Only

C21H28ClFN2O3S

442.98

(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC 50 value of 3.3 microM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 microM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.

O=S(C1=CC(F)=CC=C1C)(N[C@H]2CN(CC3=CC=C(OC(C)C)C=C3)CC2)=O.[H]Cl

12352200