(R)-Plevitrexed [153537-74-7]

MedChem Express

(R)-Plevitrexed [153537-74-7]

10

153537-74-7

Research Use Only

C26H25FN8O4

532.53

(R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed[1]. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor[2]. (R)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

O=C(NC(C)=N1)C2=C1C=C(C)C(CN(C3=CC=C(C(N[C@@H](C(O)=O)CCC4=NNN=N4)=O)C(F)=C3)CC#C)=C2

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