R892
HY-103294
Molecular Weight1154.36
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameR892
- Delivery Days Customer9
- CertificationResearch Use Only
- Molecular FormulaC58H83N13O12
- Molecular Weight1154.36
- Scientific DescriptionR892 is a selective and efficient brady K i nin B1 receptor antagonist with significant antagonistic activity. The pA2 values of R892 in human and rabbit B1 receptors are 8.8 and 8.6 respectively, indicating its strong anti-activity at these receptors. R892 exhibits selectivity with ID50 values of 2.8 nM and >600 nM for B1 and B2 receptors, respectively, and has no endogenous agonist activity. R892 is resistant to aminopeptidase and kininase II (ACE) degradation and exhibits metabolic stability [1] .
- SMILESO=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@@H](NC(C)=O)CCCCN)=O)=O)N2[C@@H](CCC2)C(NCC(N(C)[C@H](C(N[C@@H](CO)C(N[C@@H](C(N[C@H](C(O)=O)[C@@H](C)CC)=O)CC3=CC4=CC=CC=C4C=C3)=O)=O)CC5=CC=CC=C5)=O)=O
- UNSPSC12352200