RA839

MedChem Express

RA839 [1832713-02-6]

10

1832713-02-6

Research Use Only

98.54

C25H28N2O4S

452.57

RA839 is a noncovalent small molecule binder to Keap1 with a K d of ~6 microM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2 [1] .

O=C([C@@H]1CN(C2=C3C=CC=CC3=C(NS(=O)(C4=C(C)C(C)=CC(C)=C4C)=O)C=C2)CC1)O

2°C to 8°C

12352200