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Rabbit Human Secretory Component (free and bound) antibody

Research Use Only
ORB21858
Biorbyt
ReactivityHuman
Product group Antibodies
TargetPIGR
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Overview

  • Supplier
    Biorbyt
  • Product Name
    Rabbit Human Secretory Component (free and bound) antibody
  • Delivery Days Customer
    16
  • Applications Supplier
    ELISA, IP
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID5284
  • Target name
    PIGR
  • Target description
    polymeric immunoglobulin receptor
  • Target synonyms
    hepatocellular carcinoma associated protein TB6; poly-Ig receptor; polymeric immunoglobulin receptor
  • Host
    Rabbit
  • Protein IDP01833
  • Protein Name
    Polymeric immunoglobulin receptor
  • Scientific Description
    Precipitating polyclonal rabbit antiserum to human secretory component. Secretory component is present in human secretions bound to secretory IgA (sIgA) and in free form. Secretory IgA (sIgA) functions as a dimer or polymer and accounts for almost all specific mucosal antibody activity. A molecule of sIgA is made up of two molecules of IgA, one J chain and one SC (MW 65,000). The dimer IgA is transported into secretions by its binding to the SC on the epithelial cells. Under normal conditions, sIgA contains both subclasses IgA1 and IgA2, since both are capable of binding SC. SC also has an affinity for polymeric IgM. Purified free human secretory component isolated from pooled milk is used for immunization. Freunds complete adjuvant is used in the first step of the immunization procedure.
  • Reactivity
    Human
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203