Rabbit Serum Against Human Secretory Component

Biorbyt

Rabbit Serum Against Human Secretory Component

16

Dot Blot, ImmunoElectrophoresis

DOT, IEP

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Precipitating polyclonal rabbit antiserum to free human secretory component. Secretory component is present in human secretions bound to secretory IgA (sIgA) and in free form. Secretory IgA (sIgA) functions as a dimer or polymer and accounts for almost all specific mucosal antibody activity. A molecule of sIgA is made up of two molecules of IgA, one J chain and one SC (MW 65,000). The dimer IgA is transported into secretions by its binding to the SC on the epithelial cells. Under normal conditions, sIgA contains both subclasses IgA1 and IgA2, since both are capable of binding SC. SC also has an affinity for polymeric IgM. Purified free human secretory component isolated from immunoglobulin deficient milk is used for immunization. Freunds complete adjuvant is used in the first step of the immunization procedure.

Secretory component is present in human secretions bound to secretory IgA (sIgA) and in free form. Secretory IgA (sIgA) functions as a dimer or polymer and accounts for almost all specific mucosal antibody activity. A molecule of sIgA is made up of two mo

2°C to 8°C,-20°C

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