(Rac)-BDA-366

MedChem Express

(Rac)-BDA-366

14

C24H29N3O4

423.50

(Rac)-BDA-366 (example 2) is the despinner of BDA-366 (HY-101083). BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM), binding Bcl-2 -BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells [1] [2] .

O=C1C2=C(NCC3OC3)C=CC(NCC(O)CN(CC)CC)=C2C(C4=CC=CC=C41)=O

12352200