(Rac)-Nutlin-3

MedChem Express

(Rac)-Nutlin-3

14

C30H30Cl2N4O4

581.49

(Rac)-Nutlin-3 (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor ( IC 50 =90 nM). (Rac)-Nutlin-3 inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis . (Rac)-Nutlin-3 has the potential for the study of TP53 wild-type ovarian carcinomas [1] [2] .

O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=NC(C3=CC=C(C=C3)Cl)C1C4=CC=C(C=C4)Cl)N5CC(NCC5)=O

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