rac-Olodanrigan

MedChem Express

rac-Olodanrigan [152362-51-1]

5

152362-51-1

Research Use Only

C32H29NO5

507.58

rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT 2 receptor antagonist with IC 50 s of 75.2 nM and 2918 nM for AT 2 R and AT 1 R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve [1] .

O=C(C1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O

12352200