RAD18 Polyclonal Antibody

Reddot Biotech

RAD18 Polyclonal Antibody

5

ImmunoFluorescence

Research Use Only

1 mg/ml

Unconjugated

RAD18

RAD18 E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; postreplication repair protein hRAD18p; postreplication repair protein RAD18; RAD18 homolog; RAD18, S. cerevisiae, homolog; RING finger protein 73; RING-type E3 ubiquitin transferase RAD18; RNF73

Rabbit

IgG

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

Human, Mouse, Rat

-20°C

12352203