RAD50 Polyclonal Antibody
RD79963A
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetRAD50
Overview
- SupplierReddot Biotech
- Product NameRAD50 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID10111
- Target nameRAD50
- Target descriptionRAD50 double strand break repair protein
- Target synonymsDNA repair protein RAD50; hRad50; NBSLD; RAD50 homolog, double strand break repair protein; RAD502
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
- ReactivityHuman, Mouse
- Storage Instruction-20°C
- UNSPSC12352203