Chemical Structure
Raptinal [1176-09-6]
AG-CR1-2902
CAS Number1176-09-6
Product group Chemicals
Estimated Purity>98% (NMR)
Molecular Weight386.4
Overview
- SupplierAdipoGen Life Sciences
- Product NameRaptinal [1176-09-6]
- Delivery Days Customer10
- CAS Number1176-09-6
- CertificationResearch Use Only
- Estimated Purity>98% (NMR)
- Hazard InformationNon-hazardous,Warning
- Molecular FormulaC28H18O2
- Molecular Weight386.4
- Scientific DescriptionChemical. CAS: 1176-09-6. Formula: C28H18O2. MW: 386.4. Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4microM indicating activity across a wide range of cell lines. Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release. - Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4microM indicating activity across a wide range of cell lines. Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release.
- SMILESO=CC1(C2(C=O)C3=C(C=CC=C3)C4=C2C=CC=C4)C5=C(C=CC=C5)C6=C1C=CC=C6
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200
References
- A small molecule that induces intrinsic pathway apoptosis with unparalleled speed: R. Palchaudhuri, et al.; Cell Rep. 13, 2027 (2015)