Anti-Ms CD11b Purified Low Endotoxin

EXBIO

Rat Monoclonal to CD11b (mouse) / Mac-1 alpha

7

The rat monoclonal antibody M1/70 detects an extracellular epitope of CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin t

Functional application: In vitro blocking of CD11b. Flow cytometry: Recommended dilution: 1 microg/ml.

Functional Assay, Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

M1/70

1 mg/ml

IgG2b

CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.

Human, Mouse, Primate, Rabbit

2°C to 8°C

12352203