ProductsBack/Rb antibody [13A10]

IHC-P analysis of human tonsil tissue using GTX01934 Rb antibody [13A10]. Note intense nuclear staining of epithelial cells.

Rb antibody [13A10]

GTX01934

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman

TargetRB1

Overview

Supplier
GeneTex
Product Name
Rb antibody [13A10]
Delivery Days Customer
9
Application Supplier Note
WB: 1:25-1:50. IHC-P: 1:25-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
13A10
Conjugate
Unconjugated
Gene ID5925
Target name
RB1
Target description
RB transcriptional corepressor 1
Target synonyms
OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb, pp110, retinoblastoma-associated protein, prepro-retinoblastoma-associated protein, protein phosphatase 1, regulatory subunit 130, retinoblastoma 1, retinoblastoma suspectibility protein
Host
Mouse
Isotype
IgG1
Protein IDP06400
Protein Name
Retinoblastoma-associated protein
Scientific Description
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Reactivity
Human
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Hayashi T, Takamochi K, Kohsaka S, et al. Transformation from EGFR/PTEN co-mutated lung adenocarcinoma to small cell carcinoma in lymph node metastasis. Pathol Int. 2020,70(5):295-299. doi: 10.1111/pin.12919
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Hinds B, Agulló Pérez AD, LeBoit PE, et al. Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis. J Cutan Pathol. 2017,44(8):665-671. doi: 10.1111/cup.12965
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Zhao W, Huang CC, Otterson GA, et al. Altered p16(INK4) and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer. J Oncol. 2012,2012:957437. doi: 10.1155/2012/957437
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Bhatia K, Goedert JJ, Modali R, et al. Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcome. Int J Cancer. 2010,127(6):1493-6. doi: 10.1002/ijc.25136
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Sedghizadeh PP, Mallery SR, Thompson SJ, et al. Expression of the serine protease DESC1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression. Head Neck. 2006,28(5):432-40.
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