IHC-P analysis of human tonsil tissue using GTX01934 Rb antibody [13A10]. Note intense nuclear staining of epithelial cells.
IHC-P analysis of human tonsil tissue using GTX01934 Rb antibody [13A10]. Note intense nuclear staining of epithelial cells.
Rb antibody [13A10]
GTX01934
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetRB1
Overview
- SupplierGeneTex
- Product NameRb antibody [13A10]
- Delivery Days Customer9
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID13A10
- ConjugateUnconjugated
- Gene ID5925
- Target nameRB1
- Target descriptionRB transcriptional corepressor 1
- Target synonymsexon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p105-Rb; p110-RB1; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; RB; retinoblastoma 1; retinoblastoma suspectibility protein; retinoblastoma-associated protein
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Transformation from EGFR/PTEN co-mutated lung adenocarcinoma to small cell carcinoma in lymph node metastasis. Hayashi T et al., 2020 May, Pathol IntRead more
- Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis. Hinds B et al., 2017 Aug, J Cutan PatholRead more
- Altered p16(INK4) and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer. Zhao W et al., 2012, J OncolRead more
- Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcome. Bhatia K et al., 2010 Sep 1, Int J CancerRead more
- Expression of the serine protease DESC1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression. Sedghizadeh PP et al., 2006 May, Head NeckRead more