RbAp48 + RbAp46 antibody [15G12]
GTX70236
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityHuman, Mouse
Overview
- SupplierGeneTex
- Product NameRbAp48 + RbAp46 antibody [15G12]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 0.2 - 1 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID15G12
- Concentration1 mg/ml
- ConjugateUnconjugated
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionRbAp48-15G12 recognizes full length RbAp48 (48 kDa) and RbAp46 (46 kDa), related nuclear proteins first isolated by their ability to interact with the carboxyl-terminus of the retinoblastoma protein (Rb). These two proteins are highly homologous at the amino acid level and are related functionally to members of the WD (Trp-Asp) repeat family of proteins. RbAp48 is one of the three subunits of CAF-1, can bind to histone H4 and is a subunit of human histone deacetylase HD1. Both RbAp48 and RbAp46 interact with HDAC1 and mSin3 in vivo.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- A phosphomimetic mutation in the Sall1 repression motif disrupts recruitment of the nucleosome remodeling and deacetylase complex and repression of Gbx2. Lauberth SM et al., 2007 Nov 30, J Biol ChemRead more
- A conserved 12-amino acid motif in Sall1 recruits the nucleosome remodeling and deacetylase corepressor complex. Lauberth SM et al., 2006 Aug 18, J Biol ChemRead more
- Murine Sall1 represses transcription by recruiting a histone deacetylase complex. Kiefer SM et al., 2002 Apr 26, J Biol ChemRead more
- RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Lai A et al., 2001 Apr, Mol Cell BiolRead more
- Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. Humphrey GW et al., 2001 Mar 2, J Biol ChemRead more
- An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. ONeill DW et al., 2000 Oct, Mol Cell BiolRead more
- Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. Zhang Q et al., 2000 Jul, Mol Cell BiolRead more
- BRCA1 interacts with components of the histone deacetylase complex. Yarden RI et al., 1999 Apr 27, Proc Natl Acad Sci U S ARead more
- Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. ONeill D et al., 1999 Jan 19, Proc Natl Acad Sci U S ARead more