RBM15 Polyclonal Antibody

Reddot Biotech

RBM15 Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.9 mg/ml

Unconjugated

RBM15

RNA binding motif protein 15

one twenty two protein; one twenty-two; one-twenty two protein 1; OTT; OTT1; putative RNA-binding protein 15; RNA-binding protein 15; SPEN

Rabbit

IgG

RNA-binding motif protein 15 (RBM15) belongs to the SPEN protein family,which have repressor function in several signaling pathway,and may bind to RNA through interaction with spliceosome components. It was first described as a 5,Ae≤ translocation partner of the MAL gene in t(1,22)(p13;q13) infant acute megakaryocytic leukemia,and it functions in murine hematopoiesis through modulating Notch-induced transcriptional activation,which play crucial roles in leukemogenesis. Decreasing RBM15 levels with RNA interference could inhibit the growth and proliferation,block the cell cycle,and induce apoptosis in CML cells.

Human

-20°C

12352203