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ProductsBack/RBP4 (human) ELISA Kit (Quantitative)

RBP4 (human) ELISA Kit (Quantitative)

Research Use Only
AG-45A-0035YTP
AdipoGen Life Sciences
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    RBP4 (human) ELISA Kit (Quantitative)
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    0.39 to 25ng/ml
  • Assay Sensitivity
    380pg/ml
  • Assay Specificity
    Detects human RBP4. Does not cross-react with mouse RBP4, rat RBP4, human adiponectin, human resistin, human vaspin, human leptin or human Nampt.
  • Certification
    Research Use Only
  • Scientific Description
    ELISA Assay. Detects human RBP4. Does not cross-react with mouse RBP4, rat RBP4, human adiponectin, human resistin, human vaspin, human leptin or human Nampt. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum, Urine. Range: 0.39 to 25ng/ml. Sensitivity: 380pg/ml. Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function and recent studies have shown an association between serum RBP4 levels and urinary albumin excretion. The urinary RBP4 concentration may be a valuable marker for both, insulin resistance and microalbuminuria in insulin-resistant subjects. - Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function and recent studies have shown an association between serum RBP4 levels and urinary albumin excretion. The urinary RBP4 concentration may be a valuable marker for both, insulin resistance and microalbuminuria in insulin-resistant subjects.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158

References

  • Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention: M. Blueher, et al.; Diabetes Care 35, 342 (2012)
  • The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels: S. Akbarzadeh, et al.; Cytokine 58, 295 (2012)
  • Increased plasma levels of retinol-binding protein 4 with visceral obesity is associated with cardiovascular risk factors: J.C. Won, et al.; J. Diabet. Invest. 3, 457 (2012)
  • The association of carotid intima media thickness with retinol binding protein-4 and total and high molecular weight adiponectin in type 2 diabetic patients: M. Mansouri, et al.; J. Diabet. Metab. Dis. 11, 2 (2012)
  • Effects of a Combined Aerobic and Resistance Exercise Program on C1q/TNF-Related Protein-3 (CTRP-3) and CTRP-5 Levels: H.Y. Choi, et al.; Diabetes Care 36, 3321 (2013)
  • Associations between tissue visfatin/nicotinamide, phosphoribosyltransferase (Nampt), retinol binding protein-4, and vaspin concentrations and insulin resistance in morbidly obese subjects: Z. Goktas, et al.; Mediators Inflamm. 2013, 861496 (2013)
  • Lack of relationship between cord serum angiopoietin-like protein 4 (ANGPTL4) and lipolytic activity in human neonates born by spontaneous delivery: H. Ortega-Senovilla, et al.; PLoS One 8, e81201 (2013)
  • Associations of retinol-binding protein 4 with oxidative stress, inflammatory markers, and metabolic syndrome in a middle-aged and elderly Chinese population: Y. Liu, et al.; Diabetol. Metab. Syndr. 6, 25 (2014)
  • Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLoS One 9, e99785 (2014)