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RBP4 (mouse/rat) Dual ELISA Kit

Research Use Only
AG-45A-0012YTP
AdipoGen Life Sciences
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    RBP4 (mouse/rat) Dual ELISA Kit
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    0.188 to 12ng/ml
  • Assay Sensitivity
    60pg/ml
  • Assay Specificity
    Detects mouse and rat RBP4. Does not cross-react with human RBP4, mouse adiponectin, mouse resistin, mouse Nampt, rat adiponectin, rat resistin or rat Nampt.
  • Certification
    Research Use Only
  • Scientific Description
    ELISA Assay. Detects mouse and rat RBP4. Does not cross-react with human RBP4, mouse adiponectin, mouse resistin, mouse Nampt, rat adiponectin, rat resistin or rat Nampt. Colorimetric assay. Sample Types: Cell Culture Supernatant, Serum, Urine. Range: 0.188 to 12ng/ml. Sensitivity: 60pg/ml. Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function and recent studies have shown an association between serum RBP4 levels and urinary albumin excretion. The urinary RBP4 concentration may be a valuable marker for both, insulin resistance and microalbuminuria in insulin-resistant subjects. - Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function and recent studies have shown an association between serum RBP4 levels and urinary albumin excretion. The urinary RBP4 concentration may be a valuable marker for both, insulin resistance and microalbuminuria in insulin-resistant subjects.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158

References

  • Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes: Y.M. Cho, et al.; Diabetes Care 29, 2457 (2006)
  • High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans: N. Stefan, et al.; Diabetes Care 30, 1173 (2007)
  • Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice: R. Sasaki, et al.; Biochem. Pharmacol. 74, 1619 (2007)
  • Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice: N. Mody, et al.; Am. J. Physiol. Endocrinol. Metab. 294, E785 (2008)
  • Identification and characterization of a non-retinoid ligand for retinolbinding protein 4 which lowers serum retinol-binding protein 4 levels in vivo: A. Motani, et al.; J. Biol. Chem. 284, 7673 (2009)
  • Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease: K.S. Collison, et al.; J. Lipid Res. 50, 1521 (2009)
  • Diabetes of the Liver: The Link Between nonalcoholic fatty liver disease and HFCS-55: K.S. Collison, et al.; Obesity 17, 2003 (2009)
  • Early postnatal oestradiol exposure causes insulin resistance and signs of inflammation in circulation and skeletal muscle: C. Alexanderson, et al.; J. Endocrinol. 201, 49 (2009)
  • Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory: K.S. Collison, et al.; Physiol. Behav. 99, 334 (2010)
  • Effect of dietary monosodium glutamate on HFCS-induced hepatic steatosis: expression profiles in the liver and visceral fat: K.S. Collison, et al.; Obesity (Silver Spring) 18, 1122 (2010)