RECQL5-IN-1

MedChem Express

RECQL5-IN-1

10

Research Use Only

98.19%

C25H18F6N4O2S

552.49

RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM). RECQL5-IN-1 inhibits RECQL5-WT cells and RECQL5-KO2 cells with IC50s of 4.8 microM and 19.6 microM, respectively. RECQL5-IN-1 can be used for the research of breast cancer.

FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(N[C@@H](C2=CC=CC=C2)C3=NN=C(SCC4=CC=CC=C4)O3)=O)=C1

2°C to 8°C,-20°C,-80°C

12352200