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Reduced Haloperidol
T37167
CAS Number34104-67-1
Product group Chemicals
Molecular Weight377.88
Overview
- SupplierTargetMol Chemicals
- Product NameReduced Haloperidol
- Delivery Days Customer999
- CAS Number34104-67-1
- Category SupplierChemical
- Chemical NameReduced Haloperidol
- Molecular FormulaC21H25ClFNO2
- Molecular Weight377.88
- Scientific DescriptionReduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 uM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.
- Shelf life instruction3 years
- SMILESOC(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)c1ccc(F)cc1
- Storage Instruction-20°
- UNSPSC12352200