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Resistin (human) ELISA Kit

Research Use Only
AG-45A-0023YEK
AdipoGen Life Sciences
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Resistin (human) ELISA Kit
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    0.125 to 8ng/ml
  • Assay Sensitivity
    100pg/ml
  • Assay Specificity
    Detects human resistin. Does not cross-react with mouse resistin, rat resistin, human RELM-beta, mouse RELM-alpha, mouse RELM-beta, rat RELM-alpha, human leptin or human adiponectin.
  • Certification
    Research Use Only
  • Scientific Description
    ELISA Assay. Detects human resistin. Does not cross-react with mouse resistin, rat resistin, human RELM-beta, mouse RELM-alpha, mouse RELM-beta, rat RELM-alpha, human leptin or human adiponectin. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 0.125 to 8ng/ml. Sensitivity: 100pg/ml. Resistin (FIZZ3; ADSF; Adipose tissue-specific secretory factor) is a 12.5kDa cysteine-rich adipocytokine. In rodents, increased resistin-levels impair insulin action, while genetic ablation or down-regulation of the resistin gene improves insulin sensitivity. In humans most reports identified inflammatory cells and bone marrow-derived cells as the main source of resistin, indicating a role in inflammatory responses. Plasma resistin levels were shown to be associated with C-reactive protein (CRP), inflammatory bowel disease, Crohns disease, atherosclerosis and acute pancreatitis. Atherosclerosis and obesity are increasingly viewed as chronic inflammatory conditions. Circulating resistin levels were reported to be increased in obesity and diabetes. - Resistin (FIZZ3; ADSF; Adipose tissue-specific secretory factor) is a 12.5kDa cysteine-rich adipocytokine. In rodents, increased resistin-levels impair insulin action, while genetic ablation or down-regulation of the resistin gene improves insulin sensitivity. In humans most reports identified inflammatory cells and bone marrow-derived cells as the main source of resistin, indicating a role in inflammatory responses. Plasma resistin levels were shown to be associated with C-reactive protein (CRP), inflammatory bowel disease, Crohns disease, atherosclerosis and acute pancreatitis. Atherosclerosis and obesity are increasingly viewed as chronic inflammatory conditions. Circulating resistin levels were reported to be increased in obesity and diabetes.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158

References

  • Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus: B.S. Youn, et al.; J. Clin. Endocrinol. Metab. 89, 150 (2004)
  • Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans: Y.M. Cho, et al.; Diabetologia 47, 559 (2004)
  • Correlations between umbilical and maternal serum resistin levels and neonatal birth weight: Cho GJ, et al.; Acta Obstet. Gynecol. Scand. 85, 1051 (2006)
  • Relationship of serum adiponectin and resistin levels with breast cancer risk: J.H. Kang, et al.; J. Korean Med. Sci. 22, 117 (2007)
  • Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women: K. Kwon, et al.; Kor. Circ. J. 37, 251 (2007)
  • Correlation between estrogens and serum adipocytokines in premenopausal and postmenopausal women: S.C. Hong, et al.; Menopause 14, 835 (2007)
  • Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes: The Korean atherosclerosis study (KAS): A 42-month prospective study: S. Lim, et al.; Atherosclerosis 196, 398 (2008)
  • Adipokines and Systemic Lupus Erythematosus: Relationship with Metabolic Syndrome and Cardiovascular Disease Risk Factors: M. Vadacca, et al.; J. Rheumatol. 36, 295 (2009)
  • Relationship between serum adipocytokine levels and metabolic syndrome in menopausal women: H.T. Park, et al.; Gynecol. Endocrinol. 25, 27 (2009)
  • A 12-week regimen of caloric restriction improves levels of adipokines and pro-inflammatory cytokines in Korean women with BMIs greater than 23 kg/m2: I.S. Lee, et al.; Inflamm. Res. 59, 399 (2010)