Revizinone
HY-100615
Overview
- SupplierMedChem Express
- Product NameRevizinone [133718-29-3]
- Delivery Days Customer10
- CAS Number133718-29-3
- Estimated Purity98.31
- Molecular FormulaC26H29N5O3
- Molecular Weight459.55
- Scientific DescriptionRevizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. target: phosphodiesterase (PDE)[3]; IC 50: 0.036 microM; [3] In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) was 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increased global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [4]
- SMILESO=C(N(C1CCCCC1)C)CO/N=C(C2=CC=CC=C2)/C3=CC4=C(N=C(NC(C5)=O)N5C4)C=C3
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200