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ProductsBack/RF-22c [5-Lipoxygenase Inhibitor]
Chemical Structure
Chemical Structure
Chemical Structure

RF-22c [5-Lipoxygenase Inhibitor]

Research Use Only
AG-CR1-3653
AdipoGen Life Sciences
CAS Number1680206-61-4
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight336.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    RF-22c [5-Lipoxygenase Inhibitor] [1680206-61-4]
  • Delivery Days Customer
    10
  • CAS Number
    1680206-61-4
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C20H32O4
  • Molecular Weight
    336.5
  • Scientific Description
    Chemical. CAS: 1680206-61-4. Formula: C20H32O4. MW: 336.5. Synthetic. Selective and reversible potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions. Potently inhibits 5-LO product synthesis intact human leukocytes, such as neutrophils and monocytes (IC50>22nM) and in cell-free assays (IC50>140nM) without affecting 12/15-LOs, cyclooxygenase (COX)-1/2 or arachidonic acid release. Anti-inflammatory compound. Shows pronounced effectiveness in different models of inflammation in vivo at 0.1 mg/kg; i.p. Impaired (I) bronchoconstriction in ovalbumin-sensitized mice challenged with acetylcholine, (II) exudate formation in carrageenan-induced paw edema and (III) zymosan-induced leukocyte infiltration in air pouches. - Selective and reversible potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions. Potently inhibits 5-LO product synthesis intact human leukocytes, such as neutrophils and monocytes (IC50>22nM) and in cell-free assays (IC50>140nM) without affecting 12/15-LOs, cyclooxygenase (COX)-1/2 or arachidonic acid release. Anti-inflammatory compound. Shows pronounced effectiveness in different models of inflammation in vivo at 0.1 mg/kg; i.p. Impaired (I) bronchoconstriction in ovalbumin-sensitized mice challenged with acetylcholine, (II) exudate formation in carrageenan-induced paw edema and (III) zymosan-induced leukocyte infiltration in air pouches.
  • SMILES
    CCCCCCCCCCCCC(C1=O)=C(OC)C(OC)=CC1=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes: R. Filosa, et al.; Eur. J. Med. Chem. 94, 132 (2015)
  • The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo: A.M. Schaible, et al.; Biochem. Pharmacol. 112, 60 (2016)
  • Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase: A. Peduto, et al.; Eur. J. Med. Chem. 127, 715 (2017)