RFX3 Antibody, Biotin conjugated

Cusabio

RFX3 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

RFX3

regulatory factor X3

DNA binding protein RFX3; regulatory factor X, 3 (influences HLA class II expression); transcription factor RFX3

Rabbit

IgG

Transcription factor RFX3

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Acts as a transcription factor. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.

Human

-20°C or -80°C

12352203