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Rhynchophylline [76-66-4]

Research Use Only
R3197
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 221,00
10 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Rhynchophylline [76-66-4]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Scientific Description
    Oxyindole alkaloid found in Uncaria sinensis; hERG K+ and L-type Ca2+ channel channel blocker, NMDA antagonist.; Mitrinermine
  • Storage Instruction
    Ambient
  • UNSPSC
    12352200

References

  • Zhou JY, Mo ZX, Zhou SW. Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat. Arch Pharm Res. 2010 Apr;33(4):557-65. PMID: 20422365. Hsieh CL, Ho TY, Su SY, et al. Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats. Am J Chin Med. 2009;37(2):351-60. PMID: 19507277. Gui L, Li ZW, Du R, et al. Inhibitory effect of rhynchophylline on human ether-a-go-go related gene channel. Sheng Li Xue Bao. 2005 Oct 25;57(5):648-52. PMID: 16220205. Zhang WB, Chen CX, Sim SM, et al. In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel). Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):232-8. PMID: 14668978. Shi JS, Kenneth HG. Effect of rhynchophylline on apoptosis induced by dopamine in NT2 cells. Acta Pharmacol Sin. 2002 May;23(5):445-9. PMID: 11978195. Shimada Y, Goto H, Itoh T, et al. Evaluation of the protective effects of alkaloids isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats. J Pharm Pharmacol. 1999 Jun;51(6):715-22. PMID: 10454049.