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ProductsBack/Rifamycin AF-O13 [35225-13-9]
Chemical Structure
Chemical Structure
Chemical Structure

Rifamycin AF-O13 [35225-13-9]

Research Use Only
AG-CN2-0336
AdipoGen Life Sciences
CAS Number35225-13-9
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight853
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Rifamycin AF-O13 [35225-13-9]
  • Delivery Days Customer
    10
  • CAS Number
    35225-13-9
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C46H64N2O13
  • Molecular Weight
    853
  • Scientific Description
    Ansamycin antibiotic. Potent inhibitor of nucleic acid polymerizing enzymes and of some hormone receptors. Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Inhibitor of RNA-dependent DNA polymerase of MSV. Effective against mycobacteria and therefore might be used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections. - Chemical. CAS: 35225-13-9. Formula: C46H64N2O13. MW: 853. Semisynthetic. Ansamycin antibiotic. Potent inhibitor of nucleic acid polymerizing enzymes and of some hormone receptors. Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Inhibitor of RNA-dependent DNA polymerase of MSV. Effective against mycobacteria, and therefore might be used in research of tuberculosis, leprosy and mycobacterium avium complex (MAC) infections.
  • SMILES
    OC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@H]2C)O)=O)C(/C=N/OCCCCCCCC)=C(O)C3=C4C(O[C@@](O/C=C/[C@H](OC)[C@H]([C@H]2OC(C)=O)C)(C)C4=O)=C(C)C(O)=C31
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51280000

References

  • Reverse transcriptase, RNA tumor virus transformation, and derivatives of rifamycin SV: R.C. Ting, et al.; Nat. New Biol. 236, 163 (1972)
  • Selective toxicity of rifamycin derivatives for leukaemic human leucocytes: R.G. Smith, et al.; Nat. New Biol. 236, 1166 (1972)
  • Rifamycin antibiotics: inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerases from human normal and leukemic lymphoblasts: S.S. Yang, et al.; J. Natl. Cancer Inst. 49, 7 (1972)
  • Rifamycin Derivatives Strongly Inhibiting RNA>DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses: C. Gurgo, et al.; J. Natl. Cancer Inst. 49, 61 (1972)
  • Selective inhibition of Rous sarcoma virus production in transformed chick fibroblasts by two rifamycin derivatives: S. Barlati & P. Vigier; FEBS Lett. 24, 343 (1972)
  • Inhibition of RNA polymerases from rat liver by the semi-synthetic rifampicin derivatives: P.P. Juhasz, et al.; FEBS Lett. 27, 30 (1972)
  • Mechanism of action of a rifamycin derivative (AF-013) which is active on the nucleic acid polymerases insensitive to rifampicin: S. Riva, et al.; BBRC 49, 1263 (1972)
  • Action of rifamycin derivatives on RNA polymerase of human leukemic lymphocytes: M.J. Tsai & G.F. Saunders; PNAS 70, 2072 (1973)
  • Activation of DNA polymerase of murine leukemia virus by rifamycin derivatives: S. Barlati, et al.; Intervirol. 2, 33 (1974)
  • Specific inhibition of a primer-dependent nucleotide chain elongation reaction by the rifamycin derivative AF/013; S.T. Jacob, et al.; Arch. Biochem. Biophys. 164, 771 (1974)