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ProductsBack/Rifamycin PR-14 [21240-38-0]
Chemical Structure
Chemical Structure
Chemical Structure

Rifamycin PR-14 [21240-38-0]

Research Use Only
AG-CN2-0334
AdipoGen Life Sciences
CAS Number21240-38-0
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight790.9
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Rifamycin PR-14 [21240-38-0]
  • Delivery Days Customer
    10
  • CAS Number
    21240-38-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C43H54N2O12
  • Molecular Weight
    790.9
  • Scientific Description
    Ansamycin antibiotic. Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections. - Chemical. CAS: 21240-38-0. Formula: C43H54N2O12. MW: 790.9. Semisynthetic. Ansamycin antibiotic. Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Effective against mycobacteria, and are therefore used in research of tuberculosis, leprosy and mycobacterium avium complex (MAC) infections.
  • SMILES
    OC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)[C@H](/C=C/O2)OC)OC(C)=O)O)=O)C3=C(N(C)C(C)=C3C(C)=O)C4=C5C(O[C@@]2(C)C5=O)=C(C)C(O)=C41
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51280000

References

  • Rifamycin antibiotics: inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerases from human normal and leukemic lymphoblasts: S.S. Yang, et al.; J. Natl. Cancer Inst. 49, 7 (1972)
  • Rifamycin Derivatives Strongly Inhibiting RNA>DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses: C. Gurgo, et al.; J. Natl. Cancer Inst. 49, 61 (1972)
  • Isolation and characterization of human DNA-dependent RNA polymerase: M.-J. Tsai & G.F Saunders; Biochim. Biophys. Acta 366, 61 (1974)
  • Effect of the rifamycin dimers on the activities of nucleic acid polymerases from various sources. Relation between lipophily and toxicity: M. Talpaert-Borle, et al.; J. Antibiot. 28, 580 (1975)
  • Structure-Activity Relationships and DNA Polymerases From Normal and Specificity of Inhibition of Leukemia Cells of Man and From Simian Sarcoma Virus by Rifamycin Derivatives: R.A. CiCioccio & B.I.S. Srivastava; J. Natl. Cancer Inst. 61, 1187 (1978)