Riluzole-13C,15N2 [1215552-03-6]

TargetMol Chemicals

Riluzole-13C,15N2 [1215552-03-6]

44

1215552-03-6

Chemical

Research Use Only

Riluzole-13C,15N2

C8H5F3N2OS

237.18

Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 microM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg. Formulations containing riluzole have been explored as therapeutics for slowing disease progression of amyotrophic lateral sclerosis.

3 years

[15NH2][13C]1=[15N]C=2C(=CC(OC(F)(F)F)=CC2)S1

-20°C

12352200