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RIP1 kinase inhibitor 1

Research Use Only
T12725
TargetMol Chemicals
CAS Number2095515-38-9
Product group Chemicals
Molecular Weight461.9
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    RIP1 kinase inhibitor 1
  • Delivery Days Customer
    114
  • CAS Number
    2095515-38-9
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    RIP1 kinase inhibitor 1
  • Molecular Formula
    C24H20ClN5O3
  • Molecular Weight
    461.9
  • Scientific Description
    RIP1 kinase inhibitor 1 is an orally available and brain-penetrating inhibitor of RIP1 kinase with pKi of 9.04.
  • Shelf life instruction
    3 years
  • SMILES
    O=C1C=2C(=C(Cl)N(CC3=CC=CC=C3)N2)CCN1[C@@H]4C(=O)N(C)C=5C(OC4)=CC(C#N)=CC5
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, OrallyAvailable, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409.
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