Ripk1 Antibody, FITC conjugated

Cusabio

Ripk1 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

Ripk1

receptor (TNFRSF)-interacting serine-threonine kinase 1

cell death protein RIP; D330015H01Rik; R; receptor-interacting protein 1; receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; Rip1; RIP-1; serine/threonine-protein kinase RIP

Rabbit

IgG

Receptor-interacting serine/threonine-protein kinase 1

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at \Ser-728\ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via \Lys-63\-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity). Interacts with ARHGEF2 (By similarity).

Mouse

-20°C or -80°C

12352203