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ProductsBack/RITA [213261-59-7]

RITA [213261-59-7]

Research Use Only
R3476
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 660,00
25 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    RITA [213261-59-7]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Soluble in DMSO (58 mg/ml at 25° C), ethanol (8 mg/ml at 25° C), DMF (30 mg/ml), 1:1 solution of dimethyl formamide: PBS (pH 7.2) (0.5 mg/ml, dissolve RITA first in dimethyl formamide and then dilute with PBS), and water (<1 mg/ml at 25° C).
  • Scientific Description
    p53 activator.; NSC 652287; RITA (NSC 652287); p53 Activator III, RITAReactivation of p53 and induction of tumor cell apoptosis
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Burmakin M, Shi Y, Hedström E, et al. Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro. Clin Cancer Res. 2013 Sep 15;19(18):5092-103. PMID: 23864164. Henze J, Mühlenberg T, Simon S, et al. p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors. PLoS One. 2012;7(5):e37776. PMID: 22662219. Zhao CY, Szekely L, Bao W, et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70(8):3372-81. PMID: 20395210. Yang J, Ahmed A, Poon E, et al. Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol Cell Biol. 2009 Apr;29(8):2243-53. PMID: 19223463.