RMC-4998 [2642037-07-6]

TargetMol Chemicals

RMC-4998 [2642037-07-6]

16

Chemical

Research Use Only

RMC-4998

C57H74N8O7

983.25

RMC-4998 is a molecular glue compound with potent antitumor activity, forming a ternary complex with CYPA and an activated KRAS G12C mutation. Binding of CYPA to KRAS G12C hinders the interaction between activated KRAS mutants and downstream effector proteins, obstructing proliferative cell signaling [1].

3 years

C(C)N1C(=C2C=3C1=CC=C(C3)C=4C=C(CC(NC(C(C(C)C)N5C(=O)C6(CC5)CN(C(C#CC(N(C)C)(C)C)=O)CC6)=O)C(=O)N7NC(C(=O)OCC(C)(C)C2)CCC7)C=CC4)C8=C(C(OC)C)N=CC=C8

-20°C

12352200