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ProductsBack/RN-486 [1242156-23-5]

RN-486 [1242156-23-5]

Research Use Only
R5212
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 606,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    RN-486 [1242156-23-5]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    DMSO: 24 mg/mL
  • Scientific Description
    Btk inhibitor.; RN486
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Zhao X, Huang W, Wang Y, et al. Discovery of novel Bruton's tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold. Bioorg Med Chem. 2015 Feb 15;23(4):891-901. PMID: 25596757. Hartkamp LM, Fine JS, van Es IE, et al. Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants. Ann Rheum Dis. 2014 Apr 24. [Epub ahead of print]. PMID: 24764451. Wang J, Lau KY, Jung J, et al. Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells. Eur J Immunol. 2014 Apr;44(4):1130-6. PMID: 24375473. Xu D, Kim Y, Postelnek J, et al. RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents. J Pharmacol Exp Ther. 2012 Apr;341(1):90-103. PMID: 22228807.