RNASEH2A Polyclonal Antibody
RD82018A
TargetRNASEH2A
Product group Antibodies
Overview
- SupplierReddot Biotech
- Product NameRNASEH2A Polyclonal Antibody
- Delivery Days Customer5
- Concentration1 mg/ml
- Gene ID10535
- Target nameRNASEH2A
- Target descriptionribonuclease H2 subunit A
- Target synonymsAGS4; aicardi-Goutieres syndrome 4 protein; JUNB; ribonuclease H2 subunit A; ribonuclease H2, large subunit; ribonuclease HI large subunit; ribonuclease HI subunit A; RNase H(35); RNase H2 subunit A; RNase HI large subunit; RNASEHI; RNHIA; RNHL; THSD8
- Scientific DescriptionThe protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
- Storage Instruction-20°C
- UNSPSC12352203