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ProductsBack/RNF20 Recombinant Monoclonal Antibody
Western Blot Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate All lanes: RNF20 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 114 kDa Observed band size: 114 kDa
Western Blot Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate All lanes: RNF20 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 114 kDa Observed band size: 114 kDa
Western Blot Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate All lanes: RNF20 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 114 kDa Observed band size: 114 kDa

RNF20 Recombinant Monoclonal Antibody

CSB-RA227095A0HU
Cusabio
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetRNF20
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Overview

  • Supplier
    Cusabio
  • Product Name
    RNF20 Recombinant Monoclonal Antibody
  • Delivery Days Customer
    20
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2H12
  • Conjugate
    Unconjugated
  • Gene ID56254
  • Target name
    RNF20
  • Target description
    ring finger protein 20
  • Target synonyms
    BRE1; BRE1 E3 ubiquitin ligase homolog; BRE1A; E3 ubiquitin-protein ligase BRE1A; hBRE1; homolog of S. cerevisiae BRE1; RING-type E3 ubiquitin transferase BRE1A
  • Isotype
    IgG
  • Protein IDQ5VTR2
  • Protein Name
    E3 ubiquitin-protein ligase BRE1A
  • Scientific Description
    Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of Lys-120 of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203