RNF40 Antibody, FITC conjugated

Cusabio

RNF40 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

Rabbit

IgG

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of \Lys-120\ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 \Lys-4\ and \Lys-79\ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.

Human

-20°C or -80°C

12352203