RNF5-IN-1

MedChem Express

RNF5-IN-1

9

Research Use Only

C10H8O4S

224.23

RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits alpha-1-antitrypsin (NHK) dislocation with an IC50 value of 2.7 microM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections[1].

O=C(C1=CC2=C(S1(=O)=O)C=CC=C2)OC

12352200