RO 4938581

MedChem Express

RO 4938581 [883093-10-5]

10

883093-10-5

Research Use Only

99.30

C13H8BrF2N5

352.14

RO 4938581 is a potent and selective GABA A alpha5 inverse agonist, with a K i of 4.6 nM for GABA A alpha5beta3gamma2a , and shows a lower affinity at alpha1beta3gamma2a, alpha2beta3gamma2a, alpha3beta3gamma2a ( K i , 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.

FC(C1=C2N(C3=CC=C(Br)C=C3C4=NC=NN4C2)C=N1)F

-20°C,2°C to 8°C

12352200